An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death.
The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
This book sets out to explain the clinically relevant basic mechanisms of excitotoxic neuronal death, which in the adult mammalian brain is morphologically necrotic, not apoptotic, and which involve caspase-independent mechanisms of programmed cell death.
Chapter 1 Introduction Denson G. Fujikawa
General considerations
Chapter 2 Excitotoxic programmed cell death involves caspase-independent mechanisms Ted M. Dawson and Valina L. Dawson
Chapter 3 To survive or to die: how neurons deal with it Yubin Wang, Xiaoning Bi and Michel Baudry
Traumatic Brain Injury
Chapter 4 Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches &nbsló¹
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