Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical Applications [Hardcover]

Acute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists.Introduction to the Acute Phase Response: The Acute Phase Response: An Overview (I. Kushner and A. Mackiewicz). The Negative Acute Phase Proteins (A.R. Aldred and G. Schreiber). Extrahepatic Synthesis of Acute Phase Proteins (G. Schreiber and A.R. Aldred). The Major Acute Phase Proteins-Their Structure and Possible Function in Acute Phase Response: Structure and Function of Human C-Reactive Protein (A. Agrawal, J.M. Kilpatrick, and J.E. Volanakis). The SAA Lipoprotein Family (N. Eriksen, R.L. Meek, and E. Benditt). The a1-Acid Glycoprotein: Structure and Possible Functions in the Acute Phase Response (C.B. Eap and P. Baumann). Proteinase Inhibitors: An Overview of Their Structure and Possible Function in the Acute Phase (G. Salvesen and J.J. Enghild). a1-Antitrypsin: Structure, Function, Physiology (D.H. Perlmutter). Fibrinogen: A Multifunctional Acute-Phase Protein (G.M. Fuller). Haptoglobin: Retrospectives and Perspectives (W. Dobryszycka). The Acute Phase Complement Proteins (H.R. Colten). Rat a2-Macroglobulin and Related a-Macroglobulins in the Acute Phase Response (R.C. Roberts). Rat Thiostatin: Structure and Possible Function in the Acute Phase Response (G. Schreiber and T.J. Cole). Systems in Which to Study Regulation of Acute Phase Protl£1