Adrenal Disorders [Hardcover]

In Adrenal Disorders, a panel of distinguished physicians and researchers select the most relevant new findings and integrate them into the existing body of clinical knowledge on adrenal pathologies. The book includes important reviews of disturbances in cortisol homeostasis, and new concepts regarding adrenal tumors and hereditary adrenal diseases. Also discussed are mineralocorticoids and the syndromes of mineralocortoid excess and aldosterone synthase deficiency. Authoritative and insightful, Adrenal Disorders provides physicians and scientists with a comprehensive, state-of-the-art practical guide to the devastating diseases of the adrenals that are so often difficult to diagnose and treat.Part I. The Adrenal Gland: PhysiologyOntogeny of the Hypothalamo-Pituitary-Adrenal AxisMichel Grino, Nadia Dakine, Odile Paulmyer-Lacroix, and Charles OliverAdrenal Organogenesis and Steroidogenesis: Role of Nuclear Nuclear Receptor Steroidogenic Factor-1, DAX-1, and Estrogen ReceptorMeera S. RamayyaReappraisal of Adrenal Zonation Theories Based on the Differential Regulation of Apoptosis, G. W. Wolkersd?rfer and Stefan R. BornsteinPharmacology of Glucocorticoids: An OverviewAchille Gravanis and Andrew N. MargiorisGlucocorticoid Catabolism and the 11_-Hydroxysteroid Dehydrogenase SystemJonathan R. SecklAndrogens of Adrenal OriginGeorge Mastorakos and Anthony G. DoufasStructure, Function, and Regulated Expression of the Steroidogenic Acute Regulatory (StAR) Protein: Molecular Insights into the Acute Seroidogenic Response of the Adrenals and Gonads to Trophic StimulationCaleb B. Kallen, Futoshi Arakane, Teruo Sugawara, Marianthi Kiriakidou, Staci E. Pollack, Hidemichi Watari, Lane K. Christenson, Michiko Watari, and Jerome F. Strauss IIIRegulation of Adrenocortical Function by the Sympathoadrenal System: Physiology and PathologyMonika Ehrhart-Bornstein and Stefan R. BornsteinInterleukin (IL)-1 Family of Cytokines and Corticotropin-Releasing Hormone (CRH) in the Adrenal GlandAndrlÃ3