Advances in Metallodrugs: Preparation and Applications in Medicinal Chemistry [Hardcover]

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Preface xiii

1 Metallodrugs in Medicine: Present, Past, and Future Prospects 1
Imtiyaz Yousuf and Masrat Bashir

1.1 Introduction 2

1.2 Therapeutic Metallodrugs 6

1.2.1 Anticancer Metallodrugs 6

1.2.1.1 Mechanism of Anticancer Action 7

1.2.2 Antimicrobial and Antiviral Metallodrugs 15

1.2.2.1 Antimicrobial Metallodrugs 15

1.2.2.2 Antiviral Metallodrugs 16

1.2.3 Radiopharmaceuticals and Radiodiagnostic Metallodrugs 17

1.2.4 Anti-Diabetic Metallodrugs 19

1.2.5 Catalytic Metallodrugs 22

1.3 Future Prospects 23

1.4 Conclusion 25

References 26

2 Chemotherapeutic Potential of Ruthenium Metal Complexes Incorporating Schiff Bases 41
Manzoor Ahmad Malik, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Md Ikbal Ahmed Talukdar and Athar Adil Hashmi

2.1 Introduction 42

2.2 Schiff Base Complexes of Ruthenium as Anticancer Agents 43

2.3 Conclusion 63

References 64

3 Role of Metallodrugs in Medicinal Inorganic Chemistry 71
Manish Kumar, Gyanendra Kumar, Arun Kant and Dhanraj T. Maslƒ*