Aminoacyl-tRNA Synthetases in Biology and Medicine [Paperback]

This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.Catalysis.- Emergence and Evolution.- Architecture.- Protein-protein Interactions and Multicomponent Complexes.- Interactions with RNAs.- Secretion and Circulation.- Regulatory Roles.- Neural Diseases.- Cancer.- Immune Diseases.- Pathologic Implications of Mitochondrial tRNA Synthetases .- Infectious Diseases.- Reprogramming of Genetic Code.- Novel functions of tRNAs.- Perspectives for Systems and Synthetic Bio-Medicine.19831986 Researcher, Genetic Eng. Center, KAIST, Korea
19911994 Post-doc, MIT, USA
19931994 Senior Scientist, Cubist Pharmaceuticals, USA
1994-2001 Associate Professor, Sung Kyun Kwan University, Korea
2001-present Professor, College of Pharmacy, Graduate Program in Bioinformatics , Genetic Engineering, Cancer Biology, Seoul National Univ.
1998-present Director, Center for Medicinal Protein Network and Systems Biology, Seoul National University
2008- Director, Information Center of Bio-pharmacological Network
2008- Director, Integrated Bioscience and Biotechnology Institute

1 Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases

John J. Perona, Ita Gruic-Sovulj

2 Emergence and Evolution

Tammy J. Bullwinkle, Michael Ibba

3 Architecture and Metamorphosis

Min Guo, Xiang-Lei Yang

4 ProteinProtein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases

Jong Hyun Kim, Jung Min Han, Sunghoon Kim

5 Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for CellCell Communication