Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications [Hardcover]

This book covers various aspects of antibody mediated drug delivery systems  theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.

CONTRIBUTORS xv

PREFACE xix

CHAPTER 1 ANTIBODY-MEDIATED DRUG DELIVERY SYSTEMS: GENERAL REVIEW AND APPLICATIONS
Navdeep Kaur, Karthikeyan Subramani, and Yashwant Pathak 1

1 Historical Perspective 1

2 Antibodies 2

3 Antibody Mediation 3

4 Antibody-Mediated Drug Delivery Systems 4

5 Applications 6

6 Recent Trends 9

7 Future Trends 10

CHAPTER 2 IMMUNOLIPOSOMES FOR CARDIOVASCULAR TARGETING
Tatyana Levchenko, William Hartner, and Vladimir P. Torchilin 13

1 Introduction 13

2 Immunoliposome Targeting to Pathological Regions of the Vessel Wall 14

3 Liposome Internalization by Endothelial Cells 15

4 Targeting of Atherosclerotic Lesions for Tomographic Imaging 17

5 Antibody-Mediated Liposomes for Diagnosis of Thrombosis 17

6 Thrombolytic Therapy with Immunoliposomes 18

7 Targeted Sealing of Cell Membrane Lesions: Preservation of Cell Viability 19

8 Accumulation of Liposomes and Immunoliposomes in the Ischemic Heart 21

9 Immunoliposomes as a Drulã)