Applied Antisense Oligonucleotide Technology [Paperback]

Applied Antisense Oligonucleotide Technology provides the basic concepts as well as the practical concerns associated with the use of antisense oligonucleotides to modify gene expression. Chapters include oligonucleotide chemistry, DNA triplex formation, delivery mechanisms, pharmocokinetics, toxicity, oligonucleotides.CHEMISTRY, OLD AND NEW.

Oligonucleoside Methylphosphonates: Synthesis and Properties (P. Miller).

Oligo(Nucleoside Phosphorothioate)s (P. Guga, et al.).

Modified Oligodeoxynucleotides as Antisense Therapeutics (P. Seeberger & M. Caruthers).

Novel Chemistry (K. Altmann, et al.).

OLIGONUCLEOTIDE INTERNALIZATION, MECHANISM OF ACTION, AND NON-SEQUENCE SPECIFICITY.

Cellular Uptake and Biodistribution of Oligodeoxynucleotides (B. Hanss, et al.).

Use of Cationic Lipid Complexes for Antisense Oligonucleotide Delivery (C. Bennett).

Nonantisense Effects of Antisense Oligonucleotides (L. Neckers & K. Iyer).

Ribonuclease H-Mediated Antisense Effects of Oligonucleotides and Controls for Antisense Experiments (D. Tidd).

SEQUENCE-SPECIFIC INHIBITION OF GENE EXPRESSION.

The Development of C-5 Propyne Oligonucleotides as Inhibitors of Gene Function (W. Flanagan & R. Wagner).

The Use of Antisense Oligonucleotides to Inhibit Expression of Isozymes of Protein Kinase C (N. Dean, et al.).

BCR-ABL as a Target for Antisense Intervention (S. O'Brien & T. Smetsers).

The NF-kB Transcription Factor (R. Narayanan).

Disruption of the Map Kinase Signaling Pathway Using Antisense Oligonucleotide Inhibitors Targeted to RAS and RAF Kinase (B. Monia).

Protein Kil³.