Asymmetric Synthetic Methodology [Hardcover]

This comprehensive text presents a critical discussion of the scopes and limitations of various organic synthetic methodologies that are available for performing asymmetric transformations. In addition to purely chemical methods, the book covers applications of new enzymes and other biological systems that are increasingly useful in asymmetric methodology.Introduction
Nomenclature
Why Asymmetric Synthesis?
Methods to Achieve Asymmetric Synthesis
Resolution
A Question of Scale
General Rules
Carbonyl Additions
Houk's Rule
Allylic Strain
Baldwin's Rules
Pericyclic Transition States
One-Carbon Transformations
Inversions at a Single Carbon Center
Chiral Organometallic Reagents
Other Reactions
Reactions With Carbonyl Compounds
Reactions of Carbonyl Compounds With Nucleophiles
Acetal Reactions
Other Electrophiles
Other Reactions
Reductions
Enolate Reactions of Carbonyl Compounds
Enol Ethers and Enolate Formation
Reactions of Enol Ethers and Enolates
Use of Nitrogen Derivatives
Asymmetric Deprotonations and Protonations
Reactions of Functionalized Carbonyl Systems
Alkylations of 1,2-Functionalized Carbonyl Compounds
Reductions of 1,2-Functionalized Carbonyl Compounds
Alkylations of 1,3-Functionalized Carbonyl Compounds
Reductions of 1,3-Functionalized Carbonyl Compounds
Other Systems
Aldol and Related Reactions
The Aldol Reaction: Methods of Control
The Aldol Reaction: The Role of Enolate Geometry and Metal Counterion
The Formose Reaction
Preparation and Reactions of Alkenes
Alkene Synthesis
Reactions of Alkenes
Reactions of Functionalized Alkenes
Hydrogenations
Other Transition Metal Catalyzed Reactions
Hydride Delivery Agents
Reactions of Some Functionalized Alkenes
Conjugate Additions
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