Atypical Parkinsonian Disorders Clinical and Research Aspects [Hardcover]

A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.What is an Atypical Parkinsonian Disorder?Irene LitvanHistorical Issues and Atypical Parkinsonian DisordersChristopher G. GoetzEpidemiology of Progressive Supranuclear Palsy and Multiple System AtrophyAdam Zermansky and Yoav Ben-ShlomoNeuropathology of Atypical Parkinsonian DisordersIan R. A. MackenzieAnimal Models of TauopathiesJada Lewis and Michael HuttonNeurodegenerative a-SynucleinopathiesMichel Goedert and Maria Grazia SpillantiniComputer Modeling in Basal Ganglia DisordersJos? Luis Contreras-VidalAtypical Parkinsonian Disorders: Neuropathology and NosologyCharles DuyckaertsGenetics of Atypical Parkinsonism: Implications for NosologyThomas GasserMedical History anl³.