BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease [Hardcover]

BACE inhibitors and their use in the treatment of Alzheimer's Disease

BACE (?-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery.

This book details the story of the discovery of BACE and its role in AD and comprehensively discusses:

• The development of BACE inhibitors as therapeutics for Alzheimer's disease
• The research that led to the identification of BACE
• New BACE inhibitors currently being clinically tested
• ADME (absorption, distribution, metabolism, excretion) and clinical trial designtopics not addressed in current field literature
• Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery
• Other approaches to BACE inhibition based on interaction with the precursor protein APP

By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's researchand inspire new approaches to treatment of AD.

PREFACE

ACKNOWLEDGMENTS

CONTRIBUTORS

CHAPTER 1 BACE, APP PROCESSING, AND SIGNAL TRANSDUCTION IN ALZHEIMER'S DISEASE
Dale E. Bredesen and Edward H. Koo