BetaSys Systems Biology of Regulated Exocytosis in Pancreatic -Cells [Hardcover]

BetaSys uses the example of regulated exocytosis in pancreatic ?-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications.

Systems Biology is a fast moving field. This accessible book uses the example of regulated exocytosis in pancreatic ?-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications.

Preface.- Systems biology of ?-cells - revisited.- Established facts and open questions of?the focused systems analysis of regulated?exocytosis in ?-cells  a background for a focused systems analysis approach.- Mitochondria and metabolic signals in ?-cells.- ?-cell ontogenesis and the insulin production apparatus.- The role of the cytoskeleton in transport and release of?the insulin-containing granules by pancreatic ?-cells.- The mathematical microscope making the inaccessible accessible.- Magnetic resonance imaging of pancreatic ?-cells.- Mapping the ?-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches.- In vivo applications of inorganic nanoparticles.- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts.- Bioimpedance spectroscopy.- DNA variations, impaired insulin secretion and type-2 diabetes.- Genetically programmed defects in ?-cell function.- Proteomic analysis of the pancreatic islet ?-cell secretory granule: current understanding and future opportunities.- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes.- Present state of islet transplantation for type-1 diabetes patients.- Predictive protein networks and identification of drugable targets in the ?-cell.- Nanotoxicity.- From silicon cell to silicon human.- Probing cellular dynamics with mesoscopic simulations.- What drives calcium oscillations in ?-cells? newlóÇ