Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell, and Tissue Responses [Paperback]

Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.

Protein Adsorption to Biomaterials.- Investigating Protein Adsorption via Spectroscopic Ellipsometry.- Atomic Force Microscopy Methods for Characterizing Protein Interactions with Microphase-Separated Polyurethane Biomaterials.- Molecular Simulation of Protein-Surface Interactions.- Biomolecule-Nanomaterial Interactions: Effect on Biomolecular Structure, Function, and Stability.- Phage Display as a Strategy for Designing Organic/Inorganic Biomaterials.- Extracellular Matrix-derived Ligand for Selective Integrin Binding to Control Cell Function.- Ligand-functionalized Biomaterial Surfaces: Controlled Regulation of Signaling Pathways to Direct Cell Differentiation.- Growth Factors on Biomaterial Scaffolds.- Cell and Tissue Interactions with Materials: The Role of Growth Factors.- In Vitro and In Vivo Monocyte, Macrophage, Foreign Body Giant Cell, and Lymphocyte Interactions with Biomaterials.- Development and Differentiation of Neural Stem and Progenitor Cells on Synthetic and Biologically Based Surfaces.- Toward Osteogenic Differentiation of Marrow Stromal Cells and In Vitro Production oflƒB