Biphasic Chemistry and The Solvent Case [Hardcover]

Biphasic Chemistry and The Solvent Case examines recent improvements in reaction conditions, in order to affirm the role of chemistry in the sustainable field.

This book shows that those who work within the chemistry industry support limits for the use of toxic or flammable solvents, since it reduces the purifications to simple filtrations. Thanks to commercial scavengers, solid phase syntheses are now available to all. Fluorine biphasic catalysis enables extremely efficient catalyst recycling and has a high applicability potential at the industrial level.

This book also reviews the many studies that have shown that water is a solvent of choice for most synthetic reactions. Particular traits can be obtained and the effects on thermodynamics make it possible to operate at lower temperatures, thereby achieving energy savings. Finally the great diversity of application of the reactions without solvents is illustrated.

Chapter 1. Solid-phase Supported Chemistry 1
G?raldine GOUHIER

1.1. Introduction 1

1.2. Principle of solid-phase chemistry 2

1.3. Advantages 4

1.4. Safety and environment 4

1.5. Disadvantages and limitations 5

1.6. Evolution 6

1.7. Supports: linear skeletons 6

1.8. Three-dimensional resins 7

1.8.1. Macroporous resins 7

1.8.2. Gel resins 8

1.9. Characteristics of gel supports 10

1.9.1. Functionalization rate 10

1.9.2. Swelling properties 10

1.9.3. Size of the beads 12

1.9.4. Influence of cross-linking on swelling 12

1.9.5. Diffusion effect 13

1.9.6. Influence of cross-linking on diffusion 13