Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases [Hardcover]

In cardiovascular prevention, there is classically a small number of cardiovascular risk factors to treat, such as hypertension, diabetes, hyperlipidemia and smoking excess, which are widely detected and treated. Recently, it has been widely recognized that new mechanical factors should be detected and treated and involves specifically pulsatile arterial hemodynamic (PAH) parameters such as: arterial stiffness, pulse pressure, and, to a lesser extent, augmentation index and pulse pressure amplification. The pedagogic aspect of this new CV specialty involves 3 principal parts: a.?Basic concepts and pathophysiological mechanisms of PAHb.?Clinical aspects and end-organ damage in PAHc.? Clinical pharmacology and therapeutics of PAH This book represents the first that spans basic science and clinical management of this new CV subspecialty. Much has been learned regarding the management of these patients in recent years and this book presents extensive data on the techniques needed to maximize outcomes.This book covers the basic science and clinical management of a new CV subspecialty. It presents extensive data on the techniques needed to maximize outcomes.SECTION I - Basic concepts and pathophysiological mechanisms of PAH.- Principles and definitions of arterial stiffness, wave reflections and pulse pressure amplification.- Large arteries, microcirculation and the mechanism of hypertension.- Direct measurement of local arterial stiffness and pulse pressure.- Determination of systemic and regional arterial stiffness.- Calcifications.- Mechanical stress and the arterial wall.- Pulsatile stress, arterial stiffness and endothelial function.- Endothelial-dependent vascular modulation by pulse perfusion.- Central arterial aging: humans to molecules.- Elastin, calcium and the arterial wall.- Animals models for studies of arterial stiffness.- Renin-angiotensin system, large arteries and microcirculation.- Arterial distensibility and the sympathetic nervous system.- SECTION lóH