The Blood-Brain Barrier and Drug Delivery to the CNS [Hardcover]

This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research.
Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques.
A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS

assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans

presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters

examines the multidrug resistance protein P-glycoprotein as a natural transporter

analyzes current drug designs to known requirements for transport

looks at drug delivery systems for the brain

and much more!
Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.

History and Physiology of the Blood-Brain Barrier in Relation to Delivery of Drugs to the Brain
Michael W. Bradbury
Physicochemical Factors that Influence Brain Uptake
Michael H. Abraham and James A. Platts
The Development of In Vitro Models for the Blood-Brain and Blood-CSF Barriers
Christiane Engelbertz, Dorothea Korte, Thorsten Nitz, Helml#&