Brain Norepinephrine Neurobiology and Therapeutics [Paperback]

This book examines the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain.Norepinephrine is a chemical neurotransmitter. Noradrenergic drugs have been proven effective for depression and ADHD, and drugs that directly manipulate central nervous system norepinephrine are being developed for new disease indications. This book synthesizes evidence, practice and research to highlight norepinephrine's contribution to disease and therapy.Norepinephrine is a chemical neurotransmitter. Noradrenergic drugs have been proven effective for depression and ADHD, and drugs that directly manipulate central nervous system norepinephrine are being developed for new disease indications. This book synthesizes evidence, practice and research to highlight norepinephrine's contribution to disease and therapy.Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders.Introduction: revision of an old transmitter Gregory A. Ordway; Part I. The Neurobiology of Norepinephrine: 1. Neuroanatomical and chemical organization of the locus coeruleus Kimberly L. Simpson and Rick C. S. Lin; 2. Interactions of norepinephrine with other neurotransmitl3: