Calcium Binding Proteins [Hardcover]

Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography.? The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins.? It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.

Preface xi

1 Historical Perspective 1

1.1 Biomineralization 1

1.2 Coagulation 4

1.3 Secondary Messengers (Anticipated) 6

1.4 Colloids 6

1.5 Cross-Linking and Cell Surfaces 8

1.6 Secondary Messengers (Updated) 10

1.7 Pumps Channels and Ionophores 12

1.8 Calcium Binding Proteins 1

1.9 Secondary Messengers (Yet Again) 14

1.10 Mitochondria 16

1.11 Pumps Channels and Ionophores 18

1.12 Hormones 23

1.13 Measurement 26

1.14 Biomineralization: Redux 29

2 Physiological Processes Involving Calcium Binding Proteins 33

2.1 Calcium as a Secondary Messenger 34

2.2 Calcium Buffers 41

2.3 Calcium Pumps and Channels 41

2.4 Mitochondria 42

2.5 Eubacteria 43<lcÄ