This unique book presents an approach to viewing trauma. It examines the cellular consequences of trauma at a molecular level and provides new insights into the treatment of traumatic injury, based on cellular responses. The current of trauma research is reviewed, previously unpublished information on the topic is presented, and research directions are included.Mechanisms of Lethal Cell Injury Models of Toxicity Screening Using Cultured Cells, R.L. Grant and D. Acosta, Jr. Apoptosis: Cellular Signaling and Molecular Mechanisms, R.B. Evans and J.A. Cidlowski Role of Mitochondrial Injury During Oxidative Injury to Hepatocytes: Evidence of a Mitochondrial Permeability Transition by Laser Scanning Confocal Microscopy, A.-L. Nieminen, R. Imberti, A.K. Saylor, S.A. Tesfai, B. Herman, and J.J. Lemasters Cytoprotective Strategies Glycine Cytoprotection and Inhibition of Nonlysosomal Calcium-Dependent Proteolysis During Anoxia Injury of Rat Hepatocytes, J.C. Nichols, R.C. Dickson, S.F. Bronk, and G.J. Gores Di-Calciphor-Dependent Protection against Cell Death Due to Mitochondrial Failure, D.P. Jones Role of Mitochondrial ATPase Inhibitor, IF1, in Cytoprotection During Ischemia in Slow and Fast Heart-Rate Hearts, W. Rouslin and C.W. Broge The Discovery and Pharmacology of Tirilazad Mesylate, J.M. McCall Ischemia/Reperfusion Injury The Role of Neutrophils and Reactive Oxygen Metabolites in Reperfusion Injury, B.J. Zimmerman and D.N. Granger The Inflammatory Response after Hepatic Ischemia-Reperfusion, H. Jaeschke The pH Paradox in Reperfusion Injury to Heart Cells, J.J. Lemasters, J.M. Bond, I.S. Harper, E. Chacon. H. Ohata, B. Herman, and W.E. Cascio Pathophysiology of Spinal Cord Injury in a Rat Model of Decompression Sickness, L. Marzella Stress Response and Wound Healing The Stress Response and Stress Proteins, M.E. Feder, D.A. Parsell, and S.L. Lindquist Cross Talk between HeatlĂ-