The book contains 48 articles presented at the 11th International Conference on Cerebral Vasospasm held in Cincinnati, Ohio, USA, in July 2011. This collection of papers represents a cross-section of the enormous progress that has been made towards a thorough understanding and effective treatment of neurovascular events following aneurysmal subarachnoid hemorrhage, including cerebral vasospasm. It is of interest to clinicians who wish to apply state-of-the-art knowledge to their management of this devastating condition and to basic scientists wishing to expand their understanding of cerebrovascular and neural pathophysiology related to subarachnoid hemorrhage.
CLINICAL TRIALS AND DILEMMAS: History and definition of delayed cerebral ischemia. - Clinical, transcranial Doppler ultrasound, radiological features and prognostic significance of delayed cerebral ischemia. - Identifying patient report outcomes relevant to aneurysmal subarachnoid hemorrhage follow-up. - Global cerebral atrophy after subarachnoid hemorrhage: A possible marker of acute brain injury and assessment of its impact on outcome. - Protein biomarkers in patients with subarachnoid hemorrhage, vasospasm and delayed ischemic neurological deficits. - Randomized trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2). - Angiographic vasospasm versus cerebral infarction as outcome measures after aneurysmal subarachnoid hemorrhage. - Development of Nicardipine prolonged-release implants after clipping for preventing cerebral vasospasm: From laboratory to clinical trial. - Magnesium sulphate for aneurysmal subarachnoid hemorrhage: Why, how, and current controversy. - Prolonged intravenous infusion of sodium nitrite delivers nitric oxide (NO) in healthy volunteers. Special article: Proposed mechanism of cerebral vasospasm: Our hypothesis and current topics. - NEUROCRITIl#