This detailed volume presents a comprehensive compendium of clinical metabolomics protocols covering LC-MS, GC-MS, CE-MS, and NMR-based clinical metabolomics as well as bioinformatics and study design considerations. The methodologies explored here form the core of several very promising initiatives evolving around personalized health care and precision medicine, which can be seen as complimentary to the field of clinical chemistry and aid the aforementioned field with novel disease markers and diagnostic patterns. Written for the highly successful
Methods in Molecular Biology series, chapters include brief introductions to their topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.?
Authoritative and practical, Clinical Metabolomics: Methods and Protocols aims to serve as the basis for successful communication between scientists from several fields, including chemists, biologist, bioinformaticians, and clinicians, ultimately leading to effective study design and completion.
Part I: Clinical Metabolomics and Lipidomics
1. Metabolomics as a Tool to Understand Pathophysiological Processes
??????????? Julijana Ivanisevic and Aurelien Thomas
2. Metabolomics in Immunology Research
??????????? Bart Everts
Part II: LC-MS-Based Metabolomics
3. LC-MS-Based Metabolomics of Biofluids Using All Ion Fragmentation (AIF) Acquisition
??????????? Romanas Chaleckis, Shama Naz, Isabel Meisterll, and Craig E. Wheelock
4. Lipid Mediator Metabolomics via LC-MS/MS Profiling and Analysis&l3t
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