ConjugationDeconjugation Reactions in Drug Metabolism and Toxicity [Paperback]

In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology. An up-to-date source of information of broad interest to pharmacologists and toxicologists.Advances in molecular biology describing important enzyme systems involved in drug conjugation and deconjugation reactions and recent work indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds are reviewed comprehensively. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, and Part Three reviews critically the importance of drug conjugates in pharmacology and toxicology. This volume is an up-to-date source of information on this topic and will be of broad interest to pharmacologists and toxicologists.Section I: Transferases and Hydrolases Involved in Phase II ConjugationDeconjugation Reactions, Genetic Polymorphism and Regulation of Expression.- 1 The Uridine Diphosphate Glueuronosyltransferase Multigene Family: Function and Regulation With 7 Figures.- A. Introduction.- B. The Physiological Roles of Uridine Diphosphate Glucuronosyltransferases.- I. Endogenous Compound Metabolism.- II. Drug and Xenobiotic Conjugation.- III. Role of Glucuronidation in Olfaction and Glycolipid Biosynthesis.- C. Localisation of Uridine Diphosphate Glucuronosyltransferases.- I. Tissue Distribution.- II. Topology of Uridine Diphosphate Glucuronosyltransferases in the EndoplasmiclóÒ