Cryo-Electron Microscopy, in combination with Tomography, has emerged as a new technology for visualizing molecular structures revealing the native molecular details of membranes, viruses, and cells. This comprehensive, volume brings together authoritative overviews of these methods from structural and biological perspective.
Editor
List of contributors
Foreword
Preface
SECTION I Cryo-EM in Cell Biology: Structure Determination of Protein Assemblies and Cellular Organelle
Chapter 1 Introduction on Cryogenic Electron Microscopy in Structural Biology
Krishnarao Appasani
Chapter 2 Structural Dynamics of Proteasome Regulation by Cryo-EM
Youdong Mao
Chapter 3 Cryo-EM Structures of a Ubiquitin-Specific Protease in Complex with Substrate
Martin Rennie
Chapter 4 Structural Biology of Protein Kinases and Their Regulation
Samrat Mitra, Pranita Ray, Prateeka Borar, and Smarajit Polley
Chapter 5 The Life and Times of p53: Structural Advancements to Decipher the Guardian of the Genome
Maria J. Solares, Samantha Berry, and Deborah F. Kelly
SECTION II Technology Platform and Evolving Technologies
Chapter 6 Single-Particle Cryo-EM: What Happens Inside the Black Box?
Sayan Bhakta and Marin van Heel
Chapter 7 Streptavidin Affinity Grids in the Study of MalÞ
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