Diabetes, Insulin and Alzheimer's Disease [Hardcover]

This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.

Insulin Action in the Brain and the Pathogenesis of Alzheimers Disease by Carl Ronald Kahn and Ryo Suzuki.- The Brain-insulin Connection, Metabolic Diseases and Related Pathologies by Kyriaki Gerozissis.- Insulin Mediated Neuroplasticity in the Central Nervous System by Lawrence P. Reagan.- Stress Hormones and Neuroplasticity in the Diabetic Brain by Alexis M. Stranahan and Mark P. Mattson.- Diabetes and the Brain  an Epidemiologic Perspective by Lenore J. Launer.- Cognition in Type 2 Diabetes: Brain Imaging Correlates and Vascular and Metabolic Risk Factors by Geert Jan Biessels.- The Relationship between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late-onset Alzheimers disease: an Epidemiological Perspective byJos? A. Luchsinger.- The Role of Insulin Dysregulation in Aging and Alzheimers disease by Suzanne Craft.- Is Alzheimers a Disorder of Ageing and why dont Mice get it? The Centrality of Insulin Signalling to Alzheimers disease Pathology by Simon Lovestone and Richard Killick.- PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD by Miao-Kun Sun, Thomas J. Nelson and Daniel L. Alkon.- Diet, A? Oligomers and Defective Insulin and Neurotrophic Factor Signaling in Alzheimers disease by Greg M. Cole, Qiu-Lan Ma, Fusheng Yang, Atul Deshpande, Oliver Ubeda and Sally A. Frautschy.- Serum IGF-I, Life-style, and Risk of Alzheimer?s disease by Joaquin Piriz, Takeshi Nishijima, Jose Luis Trejo and Ignacio Torres Aleman.- Subject index.

Neurons share more similarities with insulin-producing pancreatic islet cells than with any other cell type. The root of this similarity may lie in the islets evolution from an ancelóª