This book?describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.
This book reviews recent findings in the field of biomarker discovery that impact the clinical management of melanoma, including biomarkers for diagnosis and disease staging, determination of prognosis, monitoring of response to therapy and drug development.
Table of Contents:
1. Introduction to Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma
Michael J. Murphy
2. Diagnostic and Prognostic Biomarkers in Melanoma: Current State of Play
Jochen Utikal, J?rgen C. Becker, and Selma Ugurel
3. Molecular Pathogenesis of Melanoma: Established and Novel Pathways
Paolo Antonio Ascierto, Maria Libera Ascierto, Mariaelena Capone, Zendee Elaba, Michael J. Murphy, and Giuseppe Palmieri
4. Staging of Melanoma
Zendee Elaba, Michael J. Murphy, Philip Kerr, and Jane M. Grant-Kels
5. Clinical and Histopathological Parameters in Melanoma
Cheryl Bilinski, Avery LaChance, and Michael J. Murphy
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