Drug Addiction II Amphetamine, Psychotogen, and Marihuana Dependence [Paperback]

Section I Amphetamine and Psychologen Dependence.- 1 General Pharmacology of Amphetamine-Like Drugs.- A. Pharmacokinetics and Metabolism.- A. Structure-Activity Relationships Among the Amphetamines.- I. Effect of Aromatic Substitution.- II. Effect of Length of the Side Chain.- III. Effect of Substitution of the Primary Nitrogen.- IV. Effect of Substitution of the Side Chain.- V. Stereoisomers.- B. Metabolism.- I. Pathways of Metabolism.- 1. Hydroxylation of Amphetamine.- 2. Aliphatic Hydroxylation.- 3. Oxidative Deamination.- 4. N-Dealkylation.- 5. N-Oxidation.- II. Stereoselectivity in Amphetamine Metabolism.- III. Factors Influencing the Metabolism of Amphetamine.- 1. Species.- 2. Urinary pH.- 3. Other Drugs.- 4. Other Factors.- IV. Metabolism of Amphetamine in Dependent Subjects.- C. Pharmacokinetics of Amphetamine.- D. Relationship Between Blood Levels and Effect in Man.- References.- B. Effects of Amphetamine in Animals.- A. Introduction.- B. Effects of Amphetamine on Neuronal Transmission.- I. Biochemical Neuropharmacology.- 1. Adrenergic Transmission.- a) Storage of CA.- b) Uptake of CA.- c) Release of CA.- d) Enzymatic Inactivation of CA.- e) Synthesis of CA.- f) Turnover of CA.- g) Uptake into and Release from Adrenergically Innervated Tissues of Amphetamine Itself.- h) Amphetamine Metabolites and Tissue CA.- i) Summary and Conclusions.- 2. Serotoninergic (5HT) Transmission.- a) Storage of 5HT.- b) Uptake of 5HT into Neurons and Platelets.- c) Release of 5HT.- d) Enzymatic Inactivation of 5HT.- e) Synthesis and Turnover of Brain 5HT.- f) Summary and Conclusions.- 3. Cholinergic Transmission.- 4. Other Putative Transmittors.- 5. Secondary Transmission; Cyclic Adenosine-3?,5?-monophosphate (cAMP).- 6. Summary and Conclusions.- II. Functional Neuropharmacology.- 1. Effects of Amphetamine on Peripheral Noradrenergically Innervated and Other Tissues in Vivo and in Vitro.- a) The Cat Nictitating Membrane and the Rat Inferior Eyelid.- b) The Cat Iris.- c) The Guinl³a