Drug Transporters: Volume 2: Recent Advances and Emerging Technologies [Hardcover]

This book provides a comprehensive guide to state-of-the-art knowledge, techniques and tools in the transporter sciences relating to drug metabolism and pharmacokinetics. There are currently no books that can be referred to by students and industrial scientists alike for clear, detailed information on relevant drug transporter science. Regulatory authorities and pharmaceutical companies have recognized the need to understand and quantify the effects of drug transporters within the human body. Case studies and information on emerging areas will be included throughout the book. The book will be relevant to those working in drug discovery and development and can be cross promoted with other titles in the RSC Drug Discovery Series. It could also be cross-promoted with the Biomolecular Series Books and the jounal MedChemComm.Dr Glynis Nicholls has over 18 years experience within the pharmaceutical field in both academia and industry (including 7 years at GlaxoSmithKline and 5 years at AstraZeneca), specializing in drug transporter science from discovery through to clinical development. Dr Nicholls has played a leading role in writing and implementing internal transporter strategies within the industry, as well as collaborating across multiple international locations with internal and external colleagues on transporter-related projects and scientific developments, including PhD projects. Dr Kuresh Youdim has 9 years academic experience in the field of nutrition and neuroscience, plus 10 years pharmaceutical experience across multiple disciplines within drug discovery and development (including 8 years at Pfizer and 2 years at Roche) predominantly in the field of drug-drug interactions and PBPK modelling.Understanding and quantifying the effects of drug transporters within the human body is essential for modulating drug safety and efficacy. This book comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism ls+