Epigenomics From Chromatin Biology to Therapeutics [Paperback]

Experts from academia and both the biotechnology and pharmaceutical industries introduce biological, medical and methodological aspects of the emerging field of epigenomics.Leading experts from academia, the biotechnology and pharmaceutical industries introduce the emerging field of epigenomics, covering a wide range of topics and methods such as basic chromatin biology, imprinting at genome-wide level, and the role of epigenomics in disease biology and epidemiology.Leading experts from academia, the biotechnology and pharmaceutical industries introduce the emerging field of epigenomics, covering a wide range of topics and methods such as basic chromatin biology, imprinting at genome-wide level, and the role of epigenomics in disease biology and epidemiology.Understanding mechanisms of gene regulation that are independent of the DNA sequence itself  epigenetics  has the potential to overthrow long-held views on central topics in biology, such as the biology of disease or the evolution of species. High throughput technologies reveal epigenetic mechanisms at a genome-wide level, giving rise to epigenomics as a new discipline with a distinct set of research questions and methods. Leading experts from academia, the biotechnology and pharmaceutical industries explain the role of epigenomics in a wide range of contexts, covering basic chromatin biology, imprinting at a genome-wide level, and epigenomics in disease biology and epidemiology. Details on assays and sequencing technology serve as an up-to-date overview of the available technological tool kit. A reliable guide for newcomers to the field as well as experienced scientists, this is a unique resource for anyone interested in applying the power of twenty-first-century genomics to epigenetic studies.List of contributors; Foreword; Preface; Part I. Basics of Chromatin Biology and Biochemistry: 1. Introduction to epigenomics; 2. Epigenetics and its historical perspectives; 3. Functional networks of human epigenetic flÔ