Even Electron Mass Spectrometry with Biomolecule Applications [Hardcover]

In addition to the essential theoretical background and fundamental principles, this unique reference presents a detailed, step-by-step methodology for interpreting even electron mass spectrometry results. Specific chapters are devoted to: proteomics; biomolecule spectral interpretation of small molecules; biomolecule spectral interpretation of biological macromolecules; and MALDI-TOF-Postsource Decay (PSD). Chapters feature detailed examples, questions, and problems to help readers solidify their understanding of the concepts and techniques.Preface.

Acknowledgements.

Dedication.

Glossary, Abbreviations, and Definitions.

Chapter I: Introduction and Fundamentals.

1.1 Definition and Description of Mass Spectrometry.

1.2 Basic Design of Mass Analyzer Instrumentation.

1.3 Mass Spectrometry of Protein, Metabolite, and Lipid Biomolecules.

1.3.1 Proteomics.

1.3.2 Metabolomics.

1.3.3 Lipidomics.

1.4 Fundamental Studies of Biological Compound Interactions.

1.5 Mass-to-Charge Ratio (m/z) - How the Mass Spectrometer Separates Ions.

1.6 Exact Mass versus Nominal Mass.

1.7 Mass Accuracy and Resolution.

1.8 High Resolution Mass Measurements.

1.9 Rings Plus Double Bonds (r + db).

1.10 The Nitrogen Rule in Mass Spectrometry.

1.11 Chapter Problems.

1.12 References.

Chapter II: Ionization in Mass Spectrometry.

2.1 Ionization Techniques and Sources.

2.2 Electron Ionization (EI).

2.3 Chemical Ionization (CI).

2.3.1 Positive Chemical Ionization.

2.3.2 Negative Chemical Ionization.

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