The book provides an intensive overview on exercise for cardiovascular disease prevention and treatment, from basic research to clinical practice. The volume firstly summarizes the acute and chronic response to exercise. Secondly, evidence for exercise as medicine for the heart based on clinical studies and basic research is summarized. Thirdly, molecular mechanisms mediating the beneficial effects of exercise including IGF-1-PI3K-AKT signalling, NO signalling, C/EBPB-Cited4 signalling, Non-coding RNAs, epigenetic regulators, mitochondria adaption and exosomes are presented. Finally, exercise dosing, prescription and future prospects are provided. This book will provide valuable reference for researchers in cell biology, physiology, as well as physician, physical?therapist in cardiology, sport medicine, etc.
Part I: Overview.- Chapter 1: Physical inactivity and the economic and health burdens due to cardiovascular disease: exercise as medicine (Mark Hamer).- Part II: Cardiac Exercise Physiology.- Chapter 2: Acute and chronic response to exercise in athletes: the Supernormal Heart (Antonello DAndrea).- Chapter 3: The effects of exercise on cardiovascular biomarkers: new insights, recent data, and applications (Lin Che).- Chapter 4: Acute and chronic exercise in animal models (Vu Thi Thu).- Part III: Cardiac Cells Adaptations in Exercise.- Chapter 5 Structural, contractile and electrophysiological adaptations of cardiomyocytes to chronic exercise (Krzesiak A).- Chapter 6: Formation of new cardiomyocytes in exercise (Liang Shen).- Chapter 7: Physical exercise can spur beneficial neoangiogenesis and microvasculature remodeling within the heart - our salvation? (Michal Miko).- Chapter 8 The non-cardiomyocyte cells of heart. their possible roles in exercise-based cardiac regeneration, reparation and remodeling (Ivan Varga).- Part IV: Exercise benefits the Heart: Basic Science Evidence.- Chapter 9: Myocardial infarction and exercise trainingl
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