Gasotransmitters [Hardcover]

Building on the complementary information presented inGas Sensing in Cells, this will be the first book to address the structurally independent but functionally intertwined molecular and cellular event that is gasotransmitter signalling. This book will be of interest to postgraduates and researchers in biochemistry, molecular biology and metallobiology. It will also be useful to pharmacologists and medicinal chemists investigating drugs that act by altering the production and signalling of gaseous mediators as well as toxicologists studying the toxic mechanisms of gasotransmitters in the environment.Overview of Gasotransmitters and the Related Signaling Network; Production of NO  The L-arginine/NOS/NO System; Production of H2S  The L-cysteine/CSE-CBS-MST/H2S System; HO-1-derived CO is a Regulator of Vascular Function and Metabolic Syndrome; Production and Signalling Functions of Ammonia in Mammalian Cells; The Interaction of NO and H2S Signaling Systems in Biology and Medicine; Signaling by CO: Molecular and Cellular Functions; Production and Signalling of Methane; Gasotransmitters in Plants

Gasotransmitters are gas molecules produced endogenously in prokaryotic and eukaryotic cells for signalling purposes. This book provides, for the first time, a comprehensive description and systematic look at all gasotransmitters, established or proposed, since their detection in 2002. The content and scope covers the production, metabolism, and signalling roles of gasotransmitters. Conceptual advances, scientific discoveries and newly developed techniques described in this book influence our understanding of fundamental molecular and cellular events in biology and medicine.

This book serves as the state-of-the-art book for undergraduate and graduate students as well as post-doctoral fellows in biomedical disciplines and toxicologists studying the toxic mechanisms of gasotransmitters in the environment. It will also be welcomed by researchers ls+