Genetic Variants in Alzheimer's Disease [Hardcover]

Alzheimers Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex?and certain subcortical regions. In the last three years, the genetics of Alzheimers Disease has made significant advances; in fact, one could argue more than in the previous two decades.? This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimers.? These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure.? The aim of this book is to put all of the recent genetic data on these new genes into context.? Different genetic variants will be discussed, as well as biomarkers and future possibilities. This book covers recent research which has identified nine new genes, and the vital realization that new pathways could be involved in the pathogenesis of Alzheimers.?These are now targets for therapeutic intervention, which might one day lead to a cure.

The Genetics of Alzheimers disease: Introduction and Perspective for the Future.- Apolipoprotein E .- Clusterin.- PICALM.- Complement Component (3b/4b) Receptor 1(CR1).- Bridging Integrator 1 (BIN1).- ATP-binding cassette, sub-family A (ABC1), member 7 (ABCA7).- Membrane-spanning 4-domains subfamily A, MS4A cluster.- Sialic acid binding immunoglobulin-like lectin-3 (CD33).- Erythropoietin-producing human hepatocellular carcinoma (EphA1).- CD2-associated protein (CD2AP).- Other Genes Implicated in Alzheimers Disease.- The Future Role of Biomarkers in Alzheimers Disease Diagnostics.- Index.

Since 2009, a revolution has been witnessed in Alzheimers Disease genetics. New genetic links are being discovered at an unprecedented pace and our understanding of the molecular mechanisms of neurodegeneration have taken a quantum leap forward. This book provides a thorough descrilcE