Genomic Imprinting Causes and Consequences [Paperback]

This significant 1995 publication deals with genomic or parental imprinting.This significant new publication on genomic or parental imprinting has been prepared by an outstanding team of international authorities. Genomic imprinting results in the preferential expression of one allele, depending on the parent of origin. It is associated with several disease syndromes in humans. Interest in this area has expanded rapidly from the time when it was first recognised that some important hereditary characterisitics were not adequately explained by the Mendelian laws of inheritance. The chapters cover a wealth of material to help explain not only the mechanisms of genomic imprinting but its biological and medical consequences.This significant new publication on genomic or parental imprinting has been prepared by an outstanding team of international authorities. Genomic imprinting results in the preferential expression of one allele, depending on the parent of origin. It is associated with several disease syndromes in humans. Interest in this area has expanded rapidly from the time when it was first recognised that some important hereditary characterisitics were not adequately explained by the Mendelian laws of inheritance. The chapters cover a wealth of material to help explain not only the mechanisms of genomic imprinting but its biological and medical consequences.Genomic imprinting results in the preferential expression of one gene, depending on the parent of origin, and it is associated with several disease syndromes in humans. This book covers a wealth of research material on chromatin structure, epigenetics, clinical genetics, developmental biology, cancer, hypotheses of evolution, and the molecular basis of the imprinting process, which will help explain not only the mechanisms of genomic imprinting, but also its biological and medical consequences.Contributors; Part I. Genomic Imprinting in Mammals: 1. The role of imprinting in early mammalian development A. Gilligl#µ