Growth Hormone Secretagogues in Clinical Practice [Hardcover]

Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds.
Beginning with a thorough historical perspective on the discovery and evolution of GH-releasing peptides (GHRPs) as therapeutic agents, Growth Hormone Secretagogues in Clinical Practice

analyzes structural requirements for GH secretagogue efficacy

demonstrates the use of mathematical models to predict differential values of individual stimuli for GH secretion from the pituitary

reports on the development of a simple screening system based on polyclonal antibodies

discusses laboratory synthesis of agonistic analogs intended for human and veterinary use

proposes applications in managing conditions such as Turner's syndrome, acromegaly, diabetic retinopathy, glomerulosclerosis, tumors, and cancer

provides physiological evidence for the effects of GHRP on behavior with a series of trials involving voluntary and forced exercise

describes a new diagnostic test for evaluating pituitary function in slowly growing children and aging adults

explores the interactions of GH secretagogues with other hormones and endogenous substances from sex steroids to interferons

and much more!

Part 1 Scope of non-GHRH growth hormone secretagogues: synergistic release of growth hormone by GHRP and GHRH - scope and implication; structural requirements of growth hormone secretagogues; unifying mechanism of non-GHRH growth hormonesecretagogues's action; molecular cloning and characterization of human, swine and rat growth hormone secretagogues receptors; a matls‚