Handbook of Cancer Vaccines [Paperback]

An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.Part I: Basic Science of Tumor Antigens and Immune ActivationBiology of the Cancer Vaccine Immune ResponseMichael A. Morse, Timothy M. Clay, and H. Kim LyerlyThe Rational Design of T-Cell Epitopes With Enhanced ImmunogenicityJohn FikesIdentification of Tumor Antigens Using Subtraction and MicroarraysJiangchun XuTumor Antigen Discovery With T CellsPaul F. RobbinsTargeting Viral Antigens for the Treatment of MalignanciesGretchen L. Eiben, Diane M. Da Silva, Steven C. Fausch, Amanda M. Krier, I. Caroline Le Poole, Megan E. Papineau, Michael I. Nishimura, and W. Martin KastImmune Defects in CancerDmitry Gabrilovich and Vladimir PisarevEscape of Tumors From the Immune System: Role of the Transforming Growth Factor-b-Signaling PathwayGerard C. BlobePart II: General Vaccine and Immunotherapy StrategiesImmune AdjuvantsJory R. Baldridge, Susan Hand Zimmermann, and Sally P. MossmanHeterologous Prime-Boost Vaccination in Tumor Immunolƒ¬