This handbook is an in-depth and comprehensive guide for the treatment and management of patients with juvenile idiopathic arthritis. The handbook provides an informative review of the disease looking at the epidemiology, etiology and pathogenesis, issues of diagnosis and classification, consequences and complications, general treatment aspects, as well as both non pharmacologic and pharmacologic therapy whilst considering the future outlook for patients with juvenile idiopathic arthritis. Juvenile idiopathic arthritis is the most common type of arthritis found in children and adolescents, affecting about 1 in 1,000 children. It is a chronic disease which causes inflammation, pain and swelling of the affected joints and can affect joints in any part of the body. This Handbook provides an unbiased, informative discussion of the current and emerging treatments in this field.
Introduction
Disease overview
Epidemiology
Etiology and pathogenesis
Environmental factors
Genetic susceptibility
Role of humoral and cell-mediated immunity
Pathogenesis of systemic arthritis
Pathophysiology of macrophage activation syndrome
Disease classification
Classification criteria
Challenges in classification
Clinical manifestations
Systemic arthritis
Rheumatoid factor-negative polyarthritis
Rheumatoid factor-positive polyarthritis
Oligoarthritis
Enthesitis-related arthritis