Handbook of Psychopharmacology Volume 10 Neoroleptics and Schizophrenia [Paperback]

1 Structure-Activity Relationships of the Butyrophenones and Diphenylbutylpiperidines.- 1. Introduction.- 2. Structure-Activity Relationships.- 2.1. Butyrophenones.- 2.2. Diphenylbutylpiperidines.- 3. Pharmacology.- 3.1. Potency and Duration of Action.- 3.2. Oral Effectiveness.- 3.3. Antipsychotic Activity.- 3.4. Side-Effect Liability.- 4. Conclusion.- 5. References.- 2 Biochemical Actions of Neuroleptic Drugs: Focus on the Dopamine Receptor.- 1. Introduction.- 2. Early Biochemical Studies.- 3. Dopamine Metabolism and Neuroleptics.- 4. The Dopamine-Sensitive Adenylate Cyclase.- 5. Labeling the Dopamine Receptor.- 5.1. Evidence for a Two-State Model of the Dopamine Receptor.- 5.2. LSD as a Mixed AgonistAntagonist at Dopamine Receptors.- 5.3. Dopamine-Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs.- 5.4. Dopamine-Receptor Binding Increases after Destruction of Dopamine Innervation: Correlation with Behavioral Supersensitivity.- 5.5. Dopamine-Receptor Binding after Chronic Drug Treatment.- 5.6. A Radioreceptor Assay to Measure Blood Neuroleptic Levels.- 5.7. Labeling Dopamine Receptors in Brain and Pituitary with [3H]Spiroperidol.- 6. References.- 3 Behavioral Actions of Neuroleptics.- 1. Introduction.- 2. Effect on Feeding and Drinking.- 2.1. Feeding in Normal Animals.- 2.2. Recovery from Lateral Hypothalamic Syndrome.- 3. Locomotor Activity and Catalepsy.- 4. Antiamphetamine Action.- 4.1. Stereotypy.- 4.2. Mouse Jumping.- 4.3. Agitation and Oxygen Consumption.- 4.4. Circling Behavior.- 5. Avoidance Behavior.- 6. Brain Self-Stimulation.- 7. Aggression.- 7.1. Apomorphine-Induced Aggression.- 7.2. Morphine-Withdrawal Aggression.- 7.3. Isolation-Induced Aggression.- 7.4. Pain-Induced Aggression.- 8. Narcotic-Withdrawal Syndrome.- 9. Conclusions.- 10. References.- 4 Neuroleptics: Clinical Use in Psychiatry.- 1. Introduction.- 2. The Methodology of Drug Studies.- 3. Efficacy of Antipsychotic Drugs.- 3.1. Comparative Effects.- 3lÃ1