Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.
Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics in humans. This volume provides insightful views suitable for clinical scientists, and graduate and undergraduate students alike.
Chapter 1- Overview of hedgehog signaling pathway
Chi-chung Hui and Jin Jiang
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Chapter 2- Regulation of Hh morphogene gradient
G. DAngelo, F. Wendler, K. Ayers and P.P. Th?rond
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Chapter 3- Smoothened Signaling through a G-protein Effector Network
David J. Robbins and Stacey K. Ogden
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Chapter 4- Kinases and phosphatases in hedgehog signaling
Jianhang Jia
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Chapter 5- Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer
Xiaodong Cheng
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Chapter 6- Crosstalks between PKC and hedgehog signaling
Jing Li and Mark Evers
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Chapter 7- Activation of Hh signaling in human cancer
Jingwu Xie and Ervin Epstein
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