Histone Deacetylases Transcriptional Regulation and Other Cellular Functions [Paperback]

A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.I. Class I Histone DeacetylasesHistone Deacetylase 1Dominique Meunier and Christian SeiserBiochemistry of Multiprotein HDAC ComplexesAlejandro Vaquero, Michael Scher, and Danny ReinbergThe Biology of HDAC3Edward SetoThe Biology of HDAC8, a Unique Class I Histone DeacetylaseDavid Waltregny and Vincent CastronovoII. Class II Histone DeacetylasesRegulation of Muscle Gene Expression by Histone DeacetylasesTimothy A. McKinsey and Eric N. OlsonThe Class IIa Histone Deacetylases: Functions and RegulationHerbert G. Kasler and Eric VerdinHistone Deacetylases in the Response to Misfolded ProteinsJ. Andrew McKee and Tso-Pang YaoIII. Class III Histone DeacetylasesComparison of Sirtuin SequenlÓ/