Hormone Resistance and Other Endocrine Paradoxes [Paperback]

Endocrinology and Metabolism: Progress in Research and Clinical Prac? tice is a new series that has been designed to present timely, critical reviews of constantly evolving fields; to provide practical and up-to-date guidance in the solution of pertinent clinical problems; to offer an alterna? tive to the laborious search of the literature (and the often frustrating reading of highly technical articles); and to translate the language of the laboratory into that of the practice of medicine. We think that this volume and those to come will prove useful to physi? cians (and to physicians in training), as well as to investigators in a wide variety of specialties; in short, to anyone who seeks answers to questions in endocrinology and metabolism. The first chapter of this volume could well serve as a general introduc? tion to the entire series. It points out how our growing understanding of the molecular basis of biologic communication has led to the discovery of a growing number of clinical syndromes, as well as to the realization that phenotypically similar diseases may have radically different pathogenetic mechanisms and thus may require radically different therapeutic strata? gems.1. Introduction: The Journey of the Endocrine Signal: A Paradigm of Murphys Law.- I. Chemical Control of Morphogenesis.- II. Hormone Biosynthesis.- III. Hormone Storage and Release.- IV. Hormone Transport.- V. Hormone Binding and Recognition.- VI. Transduction of the Endocrine Signal.- VII. Extinction of the Endocrine Signal.- VIII. Drug-Induced Changes of the Endocrine Signal.- IX. Summary.- 2. Insulin Gene Mutations and Abnormal Products of the Human Insulin Gene.- I. Insulin Biosynthesis.- II. Abnormal Insulin Gene Products.- III. Structure-Function Relationships and Biological Activity.- IV. Clinical Relevance.- V. Summary and Perspectives.- 3. Euthyroid Hyperthyroxinemia.- I. Binding Abnormalities.- II. Hormone Resistance Syndromes.- III. Nonthyroidal Illness.- IV. Drugs.- V. Exogenoulƒx