1. Tumor Vascular Modulation: Role of Endothelial cells, Ceramide and Vascular Targeted Therapies 2. Gamma Knife: From single fraction SRS to IG-HSRT 3. CyberKnife image-guided hypofractionated stereotactic radiotherapy 4. Li5. nac-based IG-HSRT technology 5. Advanced MRI for brain metastases 6. From frame to frameless: Brain radiosurgery 7. Principles of image-guided hypofractionated stereotactic radiosurgery for brain tumors 8. Principles of image-guided hypofractionated radiotherapy of spine metastases 9. Spine stereotactic body radiotherapy for the treatment of de novo spine metastasis 10. Image-guided hypofractionated stereotactic radiotherapy for reirradiation of spinal metastases I1. G-HSRT for benign tumors of the spine 12. Postoperative spine IG-HSRT outcomes 13. Postoperative cavity image-guided stereotactic radiotherapy outcomes 14. Brain metastases image-guided hypofractionated radiation therapy: Rationale, approach, outcomes 15. Image-guided hypofractionated stereotactic whole-brain radiotherapy and simultaneous integrated boost for brain metastases 16. Image-guided hypofractionated radiation therapy for high-grade glioma 17. Hypo-fractionated stereotactic radiotherapy for meningiomas, vestibular schwannomas and pituitary adenomas 18. Radiation Necrosis 19. Vertebral compression fracture post-spine SBRT 20. Spinal cord dose limits for stereotactic body radiotherapy 21. Summary of image-guided hypofractionated stereotactic radiotherapy (IG-HSRT): Serious Late Toxicities and Strategies to Mitigate Risk 22. MR-guided focused ultrasound for brain tumors 23. Laser Thermal Therapy for Brain Tumors 24. Updates on laser interstital therapy for metastatic tumors of the spine 25. Stereotactic Radiotherapy & Intracranial Leptomeningeal Disease 26. Minimally invasive percutaneous treatment in the palliation of painful bone metastases 27. Proton stereotactic radiosurgery for brain metastases 28. The ZlC.