Immunopotentiators in Modern Vaccines [Hardcover]

Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants.

In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful.

• Provides contributions from leading international authorities in the field
• Features immunopotentiators classified by function, with well-illustrated, informative figures presenting the interaction between the immunopotentiators and the host immune system
• Lists advantages and potential hurdles for achieving a practical application for each specific immunopotentiator
• Offers US FDA perspectives which highlight how future adjuvants will be approved for new generation vaccines

1. Vaccine Adjuvants' Mode of Action: Unraveling ''the Immunologist's Dirty Little Secret? 2. The Role of Inflammasomes in Adjuvant-Driven Humoral and Cellular Immune Responses 3. Dendritic Cells as Targets of Vaccines and Adjuvants 4. Host-Derived Cytokines and Chemokines as Vaccine Adjuvants 5. Discovery of Immune Potentiators as Vaccine Adjuvants 6. Current Status of Toll-Like Receptor 4 Ligand Vaccine Adjuvants 7. Flagellins as Adjuvants of Vaccines 8. Toll-Like Receptor 7 and 8 Agonists for Vaccine Adjuvant Use 9. CpG Oligodeoxynucleotides as Adjuvants for Clinical Use 10. Advax Adjuvant: A Potent and Safe Immunopotentiator Composed of Delta Inulin 11. Natural Vaccine Adjuvanlój