This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the
Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory.?
Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.
1. Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides ??????????? Fabienne Danhier, Pierre Danhier, Nathalie Schleich, Chrystelle Po, S. Laurentc, P. Sibret, C. J?r?me, V. Poucelle, Bernard Gallez, and V?ronique Pr?at
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2. Fabrication of cRGD Conjugated Dual Responsive Micelles to Target ?v?5?Integrin Overexpressed Cancer
??????????? Huacheng He, Remant Bahadur K.C., and Peisheng Xu
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3. Copper-Free Click Chemistry Modification of Nanovectors for Integrin Targeted Cancer Therapy
??????????? Chang-Fang Wang and H?lder A. Sanl3j
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