Intracellular Traffic and Neurodegenerative Disorders [Hardcover]

Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.

Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms.- Intramembrane Proteolysis by ?-Secretase and Signal Peptide Peptidases.- Axonal Transport and Neurodegenerative Disease.- Simple Cellular Solutions to Complex Problems.- Tau and Intracellular Transport in Neurons.- Signaling Between Synapse and Nucleus During Synaptic Plasticity.- Axonal Transport of Neurotrophic Signals: An Achilles' Heel for Neurodegeneration?.- Membrane Trafficking and Targeting in Alzheimer's Disease.- Huntington's Disease: Function and Dysfunction of Huntingtin in Axonal Transport.- The Role of Retromer in Neurodegenerative Disease.- Regulation of Endocytic Trafficking of Receptors and Transporters by Ubiquitination: Possible Role in Neurodegenerative Disease.- The Sortilin-Related Receptor SORL1 is Functionally and Genetically Associated with Alzheimer's Disease.- Regulation of Transport and Processing of Amyloid Precursor Protein by the Sorting Receptor SORLA.

From the reviews:

This monograph is an up to date account of the abnormalities in axonal transport of proteins and molecules in neurons in the aging and diseased brain. & This book is meant for neuropathologists, neurologists, and advanced graduate students in the Neurosciences. I can recommend it for these professionals without hesitation. (Joseph J. Grenier, Amazon.com, November, 2013)

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting tlc