Biochemistry of Diabetes and Atherosclerosis [Paperback]

Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes.

This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.

Content.- Preface.- Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative.- Comparative analysis of the phenolic content of selected Chilean, Canadian and American Merlot red wines.- Absence of ischemic preconditioning protection in diabetic sheep hearts: Role of sarcolemmal KATP channel dysfunction.- Protein kinase B in the diabetic heart.- Inhibition of interleukin-1 ? convertase is associated with decrease of neointimal hyperplasia after coronary artery stenting in pigs.- Effects of MCC-135 on Ca2+ uptake by sarcoplasmic reticulum and myofilament sensitivity to Ca2+ in isolated ventricular muscles of rats with diabetic cardiomyopathy.- Effect of sarpogrelate on altered STZ-diabetes induced cardiovascular responses to 5-hydroxytryptamine in rats.- Mitogen-activated protein kinases in the acute diabetic myocardium.- Association between coronary endothelial dysfunction and local inflammation of atherosclerotic coronary arteries.- Arteriosclerosis in rat aortic allografts: Dynamics of cell growth, apoptosis and expression of extracellular matrix proteins.- Effect of chrlƒ­