Biological Basis of Alcohol-Induced Cancer [Hardcover]

In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated. This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer; cell signaling and cancer;?stem cells; biomarkers and?metabolomics;?aerodigestive cancers;?cancer and?the immune system and more.

Introduction.- Alcohol and breast cancer: Reconciling epidemiological and molecular data.- Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.- Alcohol and Cancer: an Overview With special Emphasis on the Role of Acetaldehyde and Cytochrome P-4502E1.- Implications of acetaldehyde-derived DNA adducts for understanding alcohol related carcinogenesis.- The role of iron in alcohol-mediated hepatocarcinogenesis.- Alcoholic Cirrhosis and Hepatocellular Carcinoma.- TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis.- Synergistic Toxic Interactions Between CYP2E1, LPS/TNF? and JNK/p38 MAP Kinase and their Implications in Alcohol-induced Liver Injury.- Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma.- Alcohol consumption, Wnt/b-catenin signaling and hepatocarcinogensis.- Alcohol and HCV: Implications for Liver Cancer.- Application ofMass Spectrometry-based Metabolomics in Identification of Early Noninvasive Biomarkers of Alcohol-Induced Liver Disease Using Mouse Model.- Alcohol Metabolism by Oral Streptococci and Interaction with Human Papillomavirus Leads to Malignant Transformation of Oral Keratinocytes.- Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenl³-