Glycosaminoglycans Chemistry and Biology [Hardcover]

Glycosaminoglycans: Chemistry and Biology emphasizes several areas of glycosaminoglycan research especially analysis and application of GAGs using a variety of approaches.?Chapters focus on chemical and enzymatic synthesis of GAGs for therapeutic purposes; biophysical and biochemical methods for studying GAG-protein interactions; molecular approaches for modulating and defining GAG biosynthesis; informatics approaches for deciphering GAG code; computational approaches for establishing specific and/or non-specific interactions and genetic and biochemical tools for manipulating/visualizing glycosaminoglycan expression and studying their functions in a variety of model organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Glycosaminoglycans: Chemistry and Biology serves as a valuable manual for cutting edge methodologies and practical tips to overcome any obstacles with experimentation pertaining to chemistry and biology of glycosaminoglycans.

Part I: Structure

?1.?????? Automated Synthesis Of Chondroitin Sulfate Oligosaccharides

Chien-Fu Liang, Heung Sik Hahm, Peter H. Seeberger

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2.?????? Enzymatic Synthesis Of Heparan Sulfate And Heparin

?April Joice, Karthik Raman, Caitlin Mencio, Maritza Quintero, Spencer Brown, Thao Kim Nu Nguyen And Balagurunathan Kuberan

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3.?????? Production Of Size-Defined Heparosan, Heparan Sulfate, and Heparin Oligosaccharides By Enzymatic Depolymerization

Spencer Brown And Balagurunathan Kuberan

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