Metallopharmaceuticals I: DNA Interactions [Paperback]

Biological inorganic chemistry is a field of research at the interface of inorganic and biological chemistry. The rapidly developing insights into the role of metals in biological systems has far-reaching implications not only for biological science but also for related disciplines, ranging from molecular medicine to the environment. In each volume the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, receives a comprehensive summary and critical overview of a topic of high current interest written by leading international experts.Anticancer Activity of Cisplatin and Related Complexes.- Development of an Orally Active Platinum Anticancer Drug: JM216.- Trans-Platinum Compounds in Cancer Therapy: A Largely Unexplored Strategy for Identifying Novel Antitumor Platinum Drugs.- Chemistry and Biology of Multifunctional DNA Binding Agents.- Role of Metal Ions in Antisense and Antigene Stategies.- Sulfoxide Ruthenium Complexes: Non Toxic Tools for the Selective Treatment of Solid Tumour Metastases.- Non-Platinum Antitumor Compounds.Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.The companion book series to the Journal of Biological Inorganic Chemistry Includes supplementary material: sn.pub/extras