Molecular Mechanisms of Metabolic Arrest: Life in Limbo [Hardcover]

Many organisms can reduce their resting metabolic rate to a state of suspended animation to allow them to survive in adverse environmental conditions. Molecular Mechanisms of Metabolic Arrest focuses on the latest opinions of molecular mechanisms and principles of dormancy regulation, highlighting various new concepts in metabolic rate control. This book will strongly appeal to all molecular and comparative scientists studying organismal responses to environmental stress. It is also of relevance to medical researchers interested in how natural systems of hypometabolism can be applied to relevant problems in medicine.Molecular Mechanisms of Metabolic Arrest focuses on the latest opinions of molecular mechanisms and principles of dormancy regulation, highlighting various new concepts in metabolic rate control.TURNING DOWN THE FIRES FOF LIFE: METABOLIC REGULATION OF HIBERNATION AND ESTIVATION. Introduction. Reversible phosphorylation and enzyme control. Signal transduction. Protein adaptation. Genes and hypometabolism. Conclusions. References. HIBERNATION, A STATE OF NATURAL TOLERANCE TO PROFOUND REDUCTION IN ORGAN BLOOD FLOW AND OXYGEN DELIVERY CAPACITY. Introduction - general features. Modulation of enzyme activity in hibernation. Hibernation induction factors. Hibernation specific factors. Adaptive changes in hibernation. Suppression of protein synthesis in brain during hibernation. Changes in gene expression during hibernation. Summary. References. THE ATP-SENSITIVE POTASSIUM CHANNEL: A METABOIC SENSOR. Introduction. The plasmalemmal K ATP channels. Conclusions. References. MITOCHONDRIAL PROTON LEAK IN METABOIC DEPRESSION. Introduction. Mitochondrial proton leak. The contribution of mitochondrial proton cycling to standard metabolic rate. The problem of mitochondrial proton cycling in metabolic depression. Proton cycling in mitochondrial isolated from metabolically depressed animals. Proton cycling in intact cells isolatlÞ