Neuroinflammation Mechanisms and Management [Paperback]

In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.I. Neuroinflammatory MechanismsMicroglia: Roles of Microglia in Chronic Neurodegenerative DiseasesPaul L. WoodApoptosis vs Nonapoptotic Mechanisms in NeurodegenerationKurt A. JellingerRole(s) of Mitogen and Stress-Activated Kinases in NeurodegenerationChristopher C. J. Miller, Steven Ackerley, Janet Brownlees, Andrew J. Grierson, and Paul ThornhillRoles of Chemokines and Their Receptors in NeuroinflammationAndrzej R. Glabinski and Richard M. RansohoffNeurotoxic Mechanisms of Nitric OxideKathleen M. K. BojeChronic Intracerelc^