Toxicology of Metals: Biochemical Aspects [Paperback]

The toxicology of metals has been concerned in the past with effects that produced clinical signs and symptoms. However, this view of metal toxicology has expanded in recent years due principally to two advances. There has been a considerable increase in our knowledge of the biochemical effects of metals. In addition, biomarkers of toxicity can now be recognized that identify toxicity at levels of exposure that do not produce overt clinical effects. Thus, the toxicology of metals is now focused on nonclinical events that reflect adverse health effects. This new awareness has produced the challenge of determining the lowest adverse level of exposure. With increasing analytical sensitivity and methodologies to detect small changes at the molecular level, the lowest level of exposure of some toxic metals, like lead, is very small. Indeed, for metals in which there is no biologic requirement, it may be questioned whether there is a level of exposure that does not produce some degree of toxicity. For essential metals, the question is being asked as to the levels at which exposure exceeds biologic require? ments and excess exposure becomes toxic. The appropriateness of health decisions and the formation of public policy are dependent on the availability of current scientific information that addresses these questions. The information in this volume is intended to be a resource for this purpose as well as a reference for students of toxicology and other health professionals.1 Transplacental Transfer of Lead and Cadmium.- A. Introduction.- I. Comparison of Human and Rodent Fetal-Maternal Blood Barriers.- II. Methods for Sampling the Human Placenta.- B. Placental Transfer of Lead.- I. Mechanism of Placental Transfer of Lead.- II. Maternal Blood Lead Levels During Pregnancy.- III. Effect of Maternal Lead on Birth Outcomes.- IV. Effect of Lead on Neurobehavioral and Cognitive Development In Utero.- V. Mechanisms for the Neurotoxicity of Lead.- C. Placental Transfer of Cadmium.l³5